Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid analgesics.In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were investigated in mice.Materials and Methods: Male adult NMRI mice were made tolerant and dependent by r
Drawing on the theory of cognitive-affective processing system and that of construal level, we propose a moderated mediation model illustrating the relationship among abusive supervision, shame, construal level, and work withdrawal.We tested this acupatch model with a two-source time-lagged survey of 387 employees from 129 work teams in central and
Abstract Background The Brazilian healthcare system is a large and complex system, specially considering its mixed public and private funding.The incidence of syphilis has increased in the last four years, in spite of the presence of an effective and available treatment.Furthermore, syphilis takes part in a group of disorders of compulsory notifica
The article presents the results of the empirical study of the value profile of convicted women demonstrating different levels of legal consciousness.The study was conducted in 2020-2022 on the basis of correctional institutions located in Siberian Federal District.The sample of the study was made up of 1029 convicted women aged 20 to 35 years serv